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Accession Type:
Network
Synaptic_
Network
Shared_Object_
Synaptic_
Network
PKC
PLA2
 Molecule
 Enzyme
 Reaction
PLCbeta
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaMKII
CaM
PP1
PP2B
PKA
AC
CaRegulation

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Parameters for PLA2 (Pathway Number 72)

Pathway Layout

Pathway Basic Parameters

Pathway NamePLA2
Pathway Entry Number 72
Accession Number 16
Accession Name Synaptic_Network
Species Generic mammalian
Tissue Neuronal
CellCompartmentSynapse
Related Pathways 3, 21, 36, 57, 62, 183, 208, 314, 331, 349, 365, 920, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994, 1000, 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065
Notes Main source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 Many inputs activate PLA2. In this model I simply take each combination of stimuli as binding to PLA2 to give a unique enzymatic activity. The Km and Vmax of these active complexes is scaled according to the relative activation reported in the papers above.

Statistics

8
5
7

Conversion format

This pathway is part of accession 16 and is completely specified in the file acc16.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc16.g   
GENESIS Format (Annotated version)    Anno_acc16.g   


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