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Reaction List for pathway Ras (Pathway Number 372) in Accession Ajay_Bhalla_2007_PKM (Accession Number 80) |
Entries are grouped according to Pathway Number and they are alternately color coded using  and  color.
Further ordering can be done to the table header.   indicates that ordering is done according to ascending or descending order.Keq is calculated only for first order reactions. Kd is calculated only for second order reactions. [nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules] |
| Reaction Name | Pathway Name / Pathway No. | Kf | Kb | Kd | tau | Reagents | |
| 1 | CaM-bind-GEF | Ras Pathway No. 372 | 199.999 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate: inact-GEF CaM-Ca4 Products: CaM-GEF | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 |
| 2 | dephosph-GEF | Ras Pathway No. 372 | 1 (s^-1) | 0 (s^-1) | - | - | Substrate: GEF* Products: inact-GEF |
| 3 | Pase | Ras Pathway No. 372 | 0.0001 (s^-1) | 0 (s^-1) | - | - | Substrate: GTP-Ras Products: GDP-Ras | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 |
| 4 | dephosph-GAP | Ras Pathway No. 372 | 0.1 (s^-1) | 0 (s^-1) | - | - | Substrate: GAP* Products: GAP | Assume a reasonably good rate for dephosphorylating it, 1/sec |