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Accession Type:
Network
MAPK_network_
2003
Shared_Object_
MAPK_network_
2003
PKC
PLA2
PLCbeta
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaMKII
 Molecule
 Enzyme
 Reaction
CaM
PP1
PP2B
PKA
AC

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Enzyme List for pathway CaMKII (Pathway Number 216)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
auton_286

Enzyme Molecule:
tot_autonomous_
CaMKII		174.9970.54explicit E-S complexCaMKII-CaM
  • CaMKII-thr286*-C
    aM
    • 2 Enzyme Activity:
    auton_305

    Enzyme Molecule:
    tot_autonomous_
    CaMKII    		175.00364explicit E-S complexCaMKII-thr286
    		CaMKII***
      See Hanson and Schulman again, for afterburst rates of phosph.
    3 Enzyme Activity:
    CaM_act_286

    Enzyme Molecule:
    tot_CaM_CaMKII    		113.6010.54explicit E-S complexCaMKII-CaM
  • CaMKII-thr286*-C
    aM
    • 4 Enzyme Activity:
    CaM_act_305

    Enzyme Molecule:
    tot_CaM_CaMKII    		113.664explicit E-S complexCaMKII-thr286
    		CaMKII***
      Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.


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