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Enzyme List for pathway MKP3 (Pathway Number 345)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
act_
transcription

Enzyme Molecule:
nuc_MAPK*		40.0044explicit E-S complexnucleotides
MKP3_synthesis
 
2 Enzyme Activity:
kenz

Enzyme Molecule:
MKP3_synthesis		0.20.014explicit E-S complexMKP3_AA
MKP-3
 
3 Enzyme Activity:
MKP3-thr-deph

Enzyme Molecule:
MKP-3		10.000144explicit E-S complexMAPK*
MAPK-tyr
  See MKP1-tyr-deph Km is twice as high to avoid saturation.
4 Enzyme Activity:
MKP3-tyr-deph

Enzyme Molecule:
MKP-3		10.000144explicit E-S complexMAPK-tyr
MAPK
  The original kinetics have been modified to obey the k2 = 4 * k3 rule, while keeping kcat and Km fixed. As noted in the NOTES, the only constraining data point is the time course of MAPK dephosphorylation, which this model satisfies. It would be nice to have more accurate estimates of rate consts and MKP-1 levels from the literature. Effective Km : 67 nM kcat = 1.43 umol/min/mg Km for MKP3 is set to 267 nM, twice as high as MKP1 version, to lessen substrate saturation.
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