DOQCS Database

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

	Name	Initial Conc. (uM)	Volume (fL)	Buffered
1	Autonomous	0	0.1309	No

2	CaMKII	12.7325	0.1309	No
	Init level is 100 holoenzymes of 10 subunits each.
3	CaMKII-CaM	0	0.1309	No

4	CAMKII-CaMCa	0	0.1309	No

5	CaMKII-CaMCa2	0	0.1309	No

6	CaMKII-CaMCa3	0	0.1309	No

7	CaMKII-CaMCa4	0	0.1309	No

8	Capped	0	0.1309	No

9	Tot-active-CaMKII	0	0.1309	No

10	Total_CaMKII	127.325	0.1309	No
	This is not directly in the Holmes model. It is a trick used in GENESIS/Kinetikit to scale activity down for intramolecular reactions. Here it is used to scale the autophosph reactions such that only neighboring subunits will phosphorylate each other. This is done by scaling down the actual conc (in the enzyme parent, Tot-active-CaMKII) by the total conc such that instead of a conc, we the fraction of nearby subunits that will be active. Note that this conc of 10000 CaMKII subunits is 10 times the true conc, since only 1/10 of the molecules are neighboring molecules.
11	Trapped-T286	0	0.1309	No

	Target	Inputs
1	Tot-active-CaMKII	CaMKII-CaMCa4 Trapped-T286 Capped Autonomous

Molecule List