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Ajay_Bhalla_
2007_ReacDiff2

Shared_Object_
Ajay_Bhalla_
2007_ReacDiff

Shared Object_
Ajay_Bhalla_
2007_ReacDiff2

Shared Object_
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		Shared Object_ Ajay_Bhalla_ 2007_ReacDiff2_ [17]
		Molecule
		Enzyme
		Reaction

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[32]

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[33]

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[34]

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[38]

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Molecule List for pathway Shared Object_Ajay_Bhalla_2007_ReacDiff2[17] (Pathway Number 786)

	Name	Initial Conc. (uM)	Volume (fL)	Buffered
1	Ca	0.08	1.5	No
2	Ca_input	0.08	1.5	Yes
3	DAG	12.2	1.5	Yes
4	MAPK*	0.0001	1.5	No
5	MKP-1	0.02	1.5	No
	MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 487-493 1993. Levels of MKP-1 are regulated, and rise in 1 hour. Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134 is 40 min. 80% deph of MAPK in 20 min Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches from jun96 on.
6	PKC-active	0.0476	1.5	No
7	PPhosphatase2A	0.9991	1.5	No
	Refs: Pato et al Biochem J 293:35-41(93); Takai&Mieskes Biochem J 275:233-239 k1=1.46e-4, k2=1000,k3=250. these use kcat values for calponin. Also, units of kcat may be in min! revert to Vmax base: k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6 CoInit assumed 0.1 uM. See NOTES for MAPK_Ras50.g. CoInit now 0.08 Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm searches from jun 96 on.

Summed Molecule List

	Target	Inputs
1	PKC-active	PKC-Ca-memb* PKC-DAG-memb* PKM-zeta

Pathway Details Molecule List Enzyme List Reaction List

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