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Accession Type:
Network
Ajay_Bhalla_
2007_ReacDiff2
Shared_Object_
Ajay_Bhalla_
2007_ReacDiff
PKC
MAPK
Ras
CaM
PKM
chain
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[1]
PKC
MAPK
Ras
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[3]
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[2]
PKC
MAPK
Ras
CaM
PKM
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[4]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[5]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[6]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[7]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[8]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[9]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[10]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[11]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[12]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[13]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[14]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[15]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[16]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[17]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[18]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[19]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[20]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[21]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[22]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[23]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[24]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[25]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[26]
PKC
MAPK
 Molecule
 Enzyme
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[27]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[28]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[29]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[30]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[31]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[32]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[33]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[34]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[35]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[36]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[37]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_Bhalla_
2007_ReacDiff2_
[38]
PKC
MAPK
Ras
CaM
PKM

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Parameters for MAPK (Pathway Number 842)

Pathway Layout

Pathway Basic Parameters

Pathway NameMAPK
Pathway Entry Number 842
Accession Number 83
Accession Name Ajay_Bhalla_2007_ReacDiff2
Species Rat
Tissue Hippocampal CA1
CellCompartmentDendrite
Related Pathways 6, 24, 35, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415, 421, 432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565, 571, 577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710, 716, 722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 848, 854, 860, 866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995, 1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066, 1103
Notes  This is a 40-compartment reaction-diffusion-transport version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 40 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec In addition, we have a forward (dendrite to soma) transport term of 1 microns/sec. This converts to a rate of 0.1/sec, but applies only to the kf. So the total kf of the diffusion 'reaction' is 0.11 for D = 1 micron^2/sec, and kb is 0.01. If D=0.1 micron^2/sec then kf = 0.101 and kb = 0.001. In addition this model has all molecules buffered in the first and last compartments. This boundary conditions says that the molecules are not drained out of the first compartment, nor do they all pile up in the last one.
The stimulus file pkm_mapk22_transp_endbuf_D1e-13_Fig4CD which was used for the model to replicate Figure 4C and 4D from the paper.

Statistics

Reactions
10
6
0

Conversion format

This pathway is part of accession 83 and is completely specified in the file acc83.g.
There is no separate file for just this pathway.
FormatFile
Native Format (GENESIS format)    acc83.g   


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Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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