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Accession Type:
Pathway
MAPK_osc
MAPK
 Molecule
 Enzyme
 Reaction

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Parameters for MAPK (Pathway Number 139)

Pathway Layout

Pathway Basic Parameters

Pathway NameMAPK
Pathway Entry Number 139
Accession Number 27
Accession Name MAPK_osc
Species Xenopus
Tissue Oocyte extract
CellCompartmentCytosol
Related Pathways 6, 24, 35, 56, 61, 75, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415, 421, 432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565, 571, 577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710, 716, 722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854, 860, 866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995, 1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066, 1103
Notes This is the oscillatory MAPK model from Kholodenko 2000 Eur J. Biochem 267:1583-1588 The original model is formulated in terms of idealized Michaelis-Menten enzymes and the enzyme-substrate complex concentrations are therefore assumed negligible. The current implementation of the model uses explicit enzyme reactions involving substrates and is therefore an approximation to the Kholodenko model. The approximation is greatly improved if the enzyme is flagged as Available which is an option in Kinetikit. This flag means that the enzyme protein concentration is not reduced even when it is involved in a complex. However, the substrate protein continues to participate in enzyme-substrate complexes and its concentration is therefore affected. Overall, this model works almost the same as the Kholodenko model but the peak MAPK-PP amplitudes are a little reduced and the period of oscillations is about 10% longer. If the enzymes are not flagged as Available then the oscillations commence only when the Km for enzyme 1 is set to 0.1 uM.

Statistics

15
10
1

Conversion format

This pathway is part of accession 27 and is completely specified in the file acc27.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc27.g   
GENESIS Format (Annotated version)    Anno_acc27.g   
MATLAB format    acc27.m   
SBML format    acc27.xml   


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Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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