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Reaction List for pathway AC (Pathway Number 136) |
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| Name | Kf | Kb | Kd | tau | Substrate | Product | |
| 1 | dephosph-PDE | 0.1 (s^-1) | 0 (s^-1) | - | - | cAMP-PDE* | cAMP-PDE |
| The rates for this are poorly constrained. In adipocytes (probably a different PDE) the dephosphorylation is complete within 15 min, but there are no intermediate time points so it could be much faster. Identity of phosphatase etc is still unknown. | |||||||
| 2 | Gs-bind-AC | 499.998 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.002(uM) | - | AC GTP.Ga | Gs.AC |
| Half-max at around 3nM = kb/kf from fig 5 in Feinstein et al PNAS USA 88 10173-10177 1991 kf = kb/1800 = 5.56e-4 kb Ofer Jacobowitz thesis (Mount Sinai 1995) data indicates it is more like 2 nM. | |||||||
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