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Accession Type:
Pathway
CDK2-CyclinA_
activation_
pathway
CDK2-CyclinA
 Molecule
 Reaction

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Reaction List for pathway CDK2-CyclinA (Pathway Number 190)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 Activation0.813
(s^-1)		0.557
(s^-1)		Keq = 0.6851(uM)0.73secCDK2cycA
CDK2cycA*
  Morris et al 2002 JBC 277(26): 23847--23853 kf and kb values not published kobs2 = 2.5 +- 0.1 /sec kf=0.813/sec and kb=0.557/sec used in simulation
2 Binding18.9999
(uM^-1 s^-1)		25
(s^-1)		Kd(bf) = 1.3158(uM)-Cdk2
CyclinA
CDK2cycA
  kf = 19/sec/uM and kb = 25/sec Morris et al (2002 june 28) J Biol Chem. 277(26):23847-53
Table 1 pp.23849.


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