 |  |  PKA |
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Reaction List for pathway PP2B (Pathway Number 219) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
Ca-bind-CaNAB | 10008
(uM^-2 s^-1) | 1
(s^-1) | Kd(af) = 0.01(uM) | - | CaNAB
Ca
Ca
| CaNAB-Ca2
| | | going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1 | | 2 |
Ca-bind-CaNAB-Ca
2 | 3.6
(uM^-2 s^-1) | 1
(s^-1) | Kd(af) = 0.527(uM) | - | Ca
Ca
CaNAB-Ca2
| CaNAB-Ca4
| | | This process is probably much more complicated and involves CaM. However, as I can't find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11 | | 3 |
CaM-Ca2-bind-CaN
AB | 0.24
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 4.1667(uM) | - | CaNAB-Ca4
CaM-TR2-Ca2
| CaMCa2-CANAB
| | | Disabled. See notes for PP2B7.g | | 4 |
CaMCa3-bind-CaNA
B | 2.238
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.4468(uM) | - | CaM-Ca3
CaNAB-Ca4
| CaMCa3-CaNAB
| | 5 |
CaMCa4-bind-CaNA
B | 600
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.0017(uM) | - | CaM-Ca4
CaNAB-Ca4
| CaMCa4-CaNAB
|
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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