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Reaction List for pathway Lambda-cl (Pathway Number 301)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 Lambda-cl_
degradation		0.0057
(s^-1)		0
(s^-1)		--Lambda-cl-1
  • Degraded_
    Lambda-cl
    •   This reaction denotes the degradation of Lambda cl, kf is chosen from a random gaussian distribution. Ref: Fig 2 Garcia & Elowitz et al. (2004) PNAS 101(30) 10955 - 60
    2 lambda-cl_mRNA_
    degradation    		0.0058
    (s^-1)    		0
    (s^-1)    		--lambda-cl_mRNA1
  • Degraded_
    lambda-cl_mRNA
    •   This reaction denotes the degradation of the lambda cl m-RNA, the half life of which is two minutes. t1/2 = 0.693/k where k denotes kf Elowitz M et al (2000) Nature 403 : 335-338
    3 Lambda-cl_
    operator_
    inhibition_
    reaction    		1000.01
    (uM^-1 s^-1)    		224
    (s^-1)    		Kd(bf) = 0.224(uM)-
  • Lambda-cl_
    operator
    TetR-1
  • Lambda-cl_
    operator_1st_
    bound
    •   It signifies the first binding of the repressor with the operator Kf = 1 /nM/sec Kb = 224 /sec Box 1 Elowitz, M. et al. (2000) Nature 403:335-338
    4 Lambda-cl_
    operator_
    inhibition_
    reaction[1]    		1000.01
    (uM^-1 s^-1)    		9
    (s^-1)    		Kd(bf) = 0.009(uM)-
  • Lambda-cl_
    operator_1st_
    bound
    TetR-1
  • Lambda-cl_
    operator_2nd_
    bound
    •   It signifies the second binding of the repressor with the operator Kf = 1 /nM/sec Kb = 9 /sec Box 1 Elowitz, M. et al. (2000) Nature 403:335-338
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