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Accession information for Quorum_repressilator (Accession Number 69)

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Accession Basic Parameters

Name Quorum_repressilator
Accession Type Network
Transcriber Sharat J. Vayttaden and Pragati Jain, NCBS
Developer Jordia Garcia-Ojalvo, Elowitz and Strogatz
Entry Date (YYYY-MM-DD) 2006-02-14 00:00:00
Species E. Coli
Tissue E.coli Expression, Transposon Tn10, Lambda phage Expression
Cell Compartment Cytosol, Extracellular
Source Garcia-Ojalvo J, Elowitz MB, Strogatz SH. Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10955-60.. ( Peer-reviewed publication )
Methodology Qualitative
Model Implementation Exact GENESIS implementation
Model Validation Approximates original data
Notes This model represents a single cell with the repressilator circuit, which is part of a population of similar cells. The repressilator circuit is a network of three proteins, i.e. LacI, TetR, Lambda-cI.
The single repressilator model is at accession number 68 in the DOQCS database.
In the current model, the LacI is coupled with LuxI which forms an Autoinducer(AI) protein, which couples to LuxR which activates LacI. The AI protein difffuses across the cell membrane so that the population of cells can interact. The lifetime ratio is the ratio between the mRNA and protein lifetimes. This ratio in different cells is chosen from a random gaussian distribution of mean 1 and standard deviation 0.05. The lifetime ratio of this example cell is 0.9837

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Native Format (GENESIS format)    acc69.g   
SBML format    acc69.xml   

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