DOQCS Database

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

Reaction List for pathway Nucleus (Pathway Number 305)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.

	Name	Kf	Kb	Kd	tau	Substrate	Product
1	GDP_ dissociation	21 (s^-1)	11 (uM^-1 s^-1)	Kd(cb) = 0.5238(uM)	-	RCC1-GDP.Ran	RCC1-Ran GDP
	Release of GDP from the GDP-Ran complex with RCC1 Kf = 21 /sec Kb = 1.1e+07 /M/sec = 1.1e+01 /uM/sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100
2	GTP.Ran_release	55 (s^-1)	99.9994 (uM^-1 s^-1)	Kd(cb) = 1.8182(uM)	-	RCC1-RanGTP	GTP.Ran-nuclear RCC1
	Release of GTP.Ran from GTP.Ran-RCC1 complex Kf = 55 /sec Kb = 1.0e+08 /M/sec = 1.0e+02 /uM/sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100
3	GTP_binding	0.6 (uM^-1 s^-1)	19 (s^-1)	Kd(bf) = 31.6669(uM)	-	RCC1-Ran GTP	RCC1-RanGTP
	Binding of GTP to GDP free Ran-RCC1 complex Kf = 0.6e+06 /M/sec = 0.6 /uM/sec Kb = 19 /sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100
4	NTF2_ dissociation[1]	0.48 (s^-1)	0 (#^-1 s^-1)	Not applicable**	-	nuclear-NTF2-GDP .Ran	GDP.Ran-nuclear NTF2
	Approximation of reaction rates to match the kinetics described by Gorlich D et al (2003) EMBO J 22(5):1088-1100
5	RCC1_binding	74.0006 (uM^-1 s^-1)	55 (s^-1)	Kd(bf) = 0.7432(uM)	-	GDP.Ran-nuclear RCC1	RCC1-GDP.Ran
	Binding of GDP-Ran complex with RCC1 Kf = 7.4e+07 /M/sec = 7.4e+01 /uM/sec Kb = 55 /sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100

Pathway Detail

Molecule List

Enzyme List

Reaction List