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Molecule Parameter List for nuclear-NTF2-GDP.Ran

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
nuclear-NTF2-GDP.Ran participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
RanGTPase70Network
Shared_Object_RanGTPase Nucleus Cytoplasm 
This model represents a concentration gradient of RanGTP across the nuclear envelope. This gradient is generated by distribution of regulators of RanGTPase. We have taken a log linear plot of graphs generated by GENESIS and compared with the experimental graphs.

nuclear-NTF2-GDP.Ran acting as a Molecule in  
RanGTPase Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
nuclear-NTF2-GDP.RanRanGTPase
Accession No. : 70
Nucleus
Pathway No. : 305
012000No
NTF2-GDP.Ran Cytoplasmic fraction of GDP bound Ran complexed with NTF2 Nuclear volume = 1.2 pL = 1.2e-15 m^3 Footnote for Table 2 Gorlich D et al (2003) EMBO J 22(5):1088-1100 Initial cytoplasmic GDP.Ran concentration = 5 uM Table II footnote

nuclear-NTF2-GDP.Ran acting as a Substrate in a reaction in  
RanGTPase Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
  • NTF2_
    dissociation[1]
  • RanGTPase
    Accession No. : 70
    Nucleus
    Pathway No. : 305
    0.48
    (s^-1)
    0
    (#^-1 s^-1)
    Not applicable**-Substrate
  • nuclear-NTF2-GDP
    .Ran


    Product
    GDP.Ran-nuclear
    NTF2
  • Approximation of reaction rates to match the kinetics described by Gorlich D et al (2003) EMBO J 22(5):1088-1100
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

    nuclear-NTF2-GDP.Ran acting as a Product in a reaction in  
    RanGTPase Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • Nucleoplasmic_
    transfer
  • RanGTPase
    Accession No. : 70
  • Shared_Object_
    RanGTPase

    Pathway No. : 304
  • 10000
    (s^-1)
    0.1
    (s^-1)
    Not applicable**-Substrate
    NTF2-GDP.Ran

    Product
  • nuclear-NTF2-GDP
    .Ran

  • Approximation to achieve Nucleoplasmic transfer as per kinetics described by Gorlich D et al (2003) EMBO J 22(5):1088-1100
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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