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Reaction List for pathway NMArginine (Pathway Number 310)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 Imidazole_
release		27
(s^-1)		0.2
(uM^-1 s^-1)		Kd(cb) = 0.0074(uM)-
  • Im-nNOS-NM-Argin
    ine
  • nNOS-NM-Arginine
    Imidazole
    •   Release of Imidazole from complex ofNM-Arginine and Imidazole bound rat brainneuronal Nitric Oxide Synthase. Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51.
    2 NM-Arginine_
    binding    		25
    (uM^-1 s^-1)    		42500
    (s^-1)    		Kd(bf) = 1700(uM)-NM-Arginine
    Im-nNOS
  • Im-nNOS-NM-Argin
    ine
    •   Binding of NM-Arginine to Imidazole bound rat brainneuronal Nitric Oxide Synthase. Only Kd is known, Kf and Kb need to be approximated accordingly to match kinetic profiles. Due to lack ofappropriate graphs the choice of Kf and Kb here is arbitrary and matches only the Kd. Kd = 1.7mM = 1700uM. Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51.
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