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Accession Type:
Pathway
NMArginine
NMArginine
 Molecule
 Reaction

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Parameters for NMArginine (Pathway Number 310)

Pathway Layout

Pathway Basic Parameters

Pathway NameNMArginine
Pathway Entry Number 310
Accession Number 74
Accession Name NMArginine
Species human
Tissue Kidney cell expressing the rat brain nNOS
CellCompartmentCytosol
Related Pathways
Notes This model is taken from the Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. This model shows kinetic binding of NMArginine to neuronal nitric oxide synthase.
Model shows the substrate (NM-Arginine) binding to nNOS in a two-step reversible fashion. First there is rapid binding equilibrium between Im-nNOS and NM-Arginine to form an intermediate that contains bound imidazole and NM-arginine. This is followed by a slower conformational change in the Im-enzyme-substrate complex that is associated with release of bound imidazole and generation of a modified enzyme-substrate complex which is detected due to spectral change. Rates approximated based on data in Table 2. The rates for first reaction are not exact since only Kd known and appropriate graphs do not exist for matching the kinetic profile.

Statistics

Enzyme sites
5
0
2

Conversion format

This pathway is part of accession 74 and is completely specified in the file acc74.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc74.g   
MATLAB format    acc74.m   
SBML format    acc74.xml   


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