 |  |  MKP3 |
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Reaction List for pathway PKC (Pathway Number 330) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
PKC-act-by-Ca | 0.6
(uM^-1 s^-1) | 0.5
(s^-1) | Kd(bf) = 0.8333(uM) | - | PKC-cytosolic
Ca
| PKC-Ca
| | | Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5 | | 2 |
PKC-act-by-DAG | 0.008
(uM^-1 s^-1) | 8.6348
(s^-1) | Kd(bf) = 1079.3729(uM) | - | DAG
PKC-Ca
| PKC-Ca-DAG
| | | Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8 | | 3 |
PKC-Ca-to-memb | 1.2705
(s^-1) | 3.5026
(s^-1) | Keq = 2.7569(uM) | 0.21sec | PKC-Ca
| PKC-Ca-memb*
| | 4 |
PKC-DAG-to-memb | 1
(s^-1) | 0.1
(s^-1) | Keq = 0.1(uM) | 0.909sec | PKC-Ca-DAG
| PKC-DAG-memb*
| | | Raise kb from .087 to 0.1 to match data from Shinomura et al. Lower kf from 1.155 to 1.0 to match data from Shinomura et al. | | 5 |
PKC-n-DAG | 0.0006
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 166.6658(uM) | - | PKC-cytosolic
DAG
| PKC-DAG
| | | kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9 |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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