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Reaction List for pathway PP2B (Pathway Number 342) |
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| Name | Kf | Kb | Kd | tau | Substrate | Product | |
| 1 | Ca-bind-CaNAB | 10008.4 (uM^-2 s^-1) | 1 (s^-1) | Kd(af) = 0.01(uM) | - | CaNAB Ca Ca | CaNAB-Ca2 |
| going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1 | |||||||
| 2 | Ca-bind-CaNAB-Ca 2 | 3.6 (uM^-2 s^-1) | 1 (s^-1) | Kd(af) = 0.527(uM) | - | Ca Ca CaNAB-Ca2 | CaNAB-Ca4 |
| This process is probably much more complicated and involves CaM. However, as I can't find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11 | |||||||
| 3 | CaM-Ca2-bind-CaN AB | 0.24 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 4.1666(uM) | - | CaNAB-Ca4 CaM-TR2-Ca2 | CaMCa2-CANAB |
| Disabled. See notes for PP2B7.g | |||||||
| 4 | CaMCa3-bind-CaNA B | 2.238 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.4468(uM) | - | CaM-Ca3 CaNAB-Ca4 | CaMCa3-CaNAB |
| 5 | CaMCa4-bind-CaNA B | 600.003 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.0017(uM) | - | CaM-Ca4 CaNAB-Ca4 | CaMCa4-CaNAB |
| Pathway Detail | Molecule List | Enzyme List | Reaction List |