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Reaction List for pathway Ras (Pathway Number 63) |
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| Name | Kf | Kb | Kd | tau | Substrate | Product | |
| 1 | dephosph-GAP | 0.1 (s^-1) | 0 (s^-1) | - | - | GAP* | GAP |
| Assume a reasonably good rate for dephosphorylating it, 1/sec | |||||||
| 2 | dephosph-GEF | 1 (s^-1) | 0 (s^-1) | - | - | GEF* | inact-GEF |
| 3 | Ras-intrinsic-GT Pase | 0.0001 (s^-1) | 0 (s^-1) | - | - | GTP-Ras | GDP-Ras |
| This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | |||||||
| Pathway Detail | Molecule List | Enzyme List | Reaction List |