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Molecule List for pathway AC (Pathway Number 289) in Accession AMPAR_CaMKII_weak_coupling (Accession Number 65) |
Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.  arrow indicates that ordering is done according to ascending or descending order.The entries are grouped according to Pathway Number and are alternately color coded using  and  color. |
| Name | Accession Type | Initial Conc. (uM) | Volume (fL) | Buffered | Sum Total Of | |||
| 1 | AC1 | Network | 0.0741 | 0.09 | No | - | ||
| Starting conc at 20 nM. Reduced conc to 10 nM, 14.8. Arnold 17 Feb 2005. Raised conc back to about 18 nM, for an nInit of precisely 1. 18 Feb. Doubled conc, to compensate for reduced ATP. 18 Feb. Doublec conc again, halved Vmax. | ||||||||
| 2 | AC1-CaM | Network | 0 | 0.09 | No | - | ||
| This version of cyclase is Calmodulin activated. Gs stims it but betagamma inhibits. | ||||||||
| 3 | AC2 | Network | 0.0741 | 0.09 | No | - | ||
| Starting at 0.015 uM. 17 Feb 2005: Raised slightly so as to have integer number of molecules. 18 Feb 2005: Doubled, to compensate for reduced ATP. | ||||||||
| 4 | AC2* | Network | 0 | 0.09 | No | - | ||
| This version is activated by Gs and by a betagamma and phosphorylation. | ||||||||
| 5 | AMP | Network | 0 | 0.09 | No | - | ||
| 6 | ATP | Network | 2000 | 0.09 | Yes | - | ||
| ATP is present in all cells between 2 and 10 mM. See Lehninger | ||||||||
| 7 | CaM.PDE1 | Network | 0 | 0.09 | No | - | ||
| Activity up 6x following Ca-CaM binding. | ||||||||
| 8 | cAMP-PDE | Network | 0.5556 | 0.09 | No | - | ||
| The levels of the PDE are not known at this time. However, enough kinetic info and info about steady-state levels of cAMP etc are around to make it possible to estimate this. 18 Feb 2005: After some playing with initial conc, it is now back at 0.5 uM. | ||||||||
| 9 | cAMP-PDE* | Network | 0 | 0.09 | No | - | ||
| This form has about 2X activity as plain PDE. See Sette et al JBC 269:28 18271-18274 1994. | ||||||||
| 10 | cAMP_in_dend | Network | 0 | 5 | No | - | ||
| Assume a 5 uM long segment of 1 uM^2 Xsection dendrite. | ||||||||
| 11 | PDE1 | Network | 2.5926 | 0.09 | No | - | ||
| CaM-Dependent PDE. Amount calculated from total rate in brain vs. specific rate. | ||||||||