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Accession Type:
Network
AMPAR_CaMKII_
weak_coupling
Shared_Object_
AMPAR_CaMKII_
weak_coupling
CaMKII
CaM
PP1
PP2B
PP1_PSD
AMPAR
PKA
AC
AMPAR_memb
PP1_CaMKII_PSD
CaMKII_PSD

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Accession information for AMPAR_CaMKII_weak_coupling (Accession Number 65)

Reaction Scheme

Accession Basic Parameters

Name AMPAR_CaMKII_weak_coupling
Accession Type Network
Transcriber Upinder S. Bhalla, NCBS
Developer Arnold Hayer and Upinder S. Bhalla, NCBS
Entry Date (YYYY-MM-DD) 2005-07-21
Species General Mammalian
Tissue Neuronal
Cell Compartment Synaptic Spine, Postsynaptic Density
Source Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )
Methodology Quantitative match to experiments, Qualitative
Model Implementation Exact GENESIS implementation
Model Validation Replicates original data , Approximates original data
Notes This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.

Conversion formats

FormatFile
Native Format (GENESIS format)    acc65.g   
MATLAB format    acc65.m   
SBML format    acc65.xml   



Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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