| Name | AMPAR_CaMKII_weak_coupling |
| Accession Type | Network |
| Transcriber | Upinder S. Bhalla, NCBS |
| Developer | Arnold Hayer and Upinder S. Bhalla, NCBS |
| Entry Date (YYYY-MM-DD) | 2005-07-21 00:00:00 |
| Species | General Mammalian |
| Tissue | Neuronal |
| Cell Compartment | Synaptic Spine, Postsynaptic Density |
| Source | Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication ) |
| Methodology | Quantitative match to experiments, Qualitative |
| Model Implementation | Exact GENESIS implementation |
| Model Validation | Replicates original data , Approximates original data |
| Notes | This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on. |
