NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Accession Type:
Pathway
NOS_Phosph_
regulation
NOS

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Accession information for NOS_Phosph_regulation (Accession Number 20)

Reaction Scheme

Accession Basic Parameters

Name NOS_Phosph_regulation
Accession Type Pathway
Transcriber Sudhir Sivakumaran, NCBS
Developer Sudhir Sivakumaran, NCBS
Entry Date (YYYY-MM-DD) 2001-12-25 00:00:00
Species rat; Mammalian
Tissue Brain - Neuronal; expressed in E.coli
Cell Compartment Cytosol
Source In-house
Methodology Quantitative match to experiments, Qualitative
Model Implementation Exact GENESIS implementation
Model Validation Approximates orginal data, Quantitatively predicts new data
Notes This model features the phosphorylation of rat brain neuronal NOS expressed in E. coli or Sf9 cells, which leads to a decrease in Vmax of the phosphorylated enzyme, with little change of both the Km for L-arginine and Kact for CaM. This is based on Hayashi Y. et al. J Biol Chem. (1999) 274(29):20597-602. They report of phosphorylatin being carried out by CaM kinases I alpha, II alpha and IV. The rates used have been obtained from their paper and from other reported experimental data.

Conversion formats

FormatFile
Native Format (GENESIS format)    acc20.g   
GENESIS Format (Annotated version)    Anno_acc20.g   
SBML format    acc20.xml   



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.