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Molecule Parameter List for nonhemebind_int | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | sGC_Stone_
Marletta | 15 | Pathway |
sGC | | This features the two step binding of NO to soluble Guanylyl Cyclase as proposed by Stone JR, Marletta MA. Biochemistry (1996) 35(4):1093-9. There is a fast step binding scheme and a slow step binding scheme. The difference lies in the binding of a NO to a non-heme site on sGC, which may not necessarily be the same site of binding during the initial binding. The rates have been directly used from their models |
nonhemebind_int acting as a Molecule in sGC_Stone_Marletta Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | nonhemebind_int | sGC_Stone_
Marletta
Accession No. : 15 | sGC
Pathway No. : 69 | 0 | 0.0016667 | No | | Here the new NO has bound to the unidentified non-heme site on the 6-coordinate complex, and this will convert to the 5-coordinate complex. this binding of a new NO to the non-heme site on the 6-coordinate complex is characteristic of the slow binding process of NO to sGC. |
nonhemebind_int acting as a Substrate in a reaction in sGC_Stone_Marletta Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | act_sGCslow | sGC_Stone_
Marletta
Accession No. : 15 | sGC
Pathway No. : 69 | 1.6
(s^-1) | 0.02
(s^-1) | Keq = 0.0125(uM) | 0.617sec | Substrate
nonhemebind_int
Product
NO.sGC5accord
| | Rates used directly from Stone and Marletta,1996, Biochemistry, 35(4):1093-1099. |
nonhemebind_int acting as a Product in a reaction in sGC_Stone_Marletta Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | NObindnonheme | sGC_Stone_
Marletta
Accession No. : 15 | sGC
Pathway No. : 69 | 5
(uM^-1 s^-1) | 25
(s^-1) | Kd(bf) = 5(uM) | - | Substrate
NO
NO.sGC6coord
Product
nonhemebind_int
| | This step is the one that differs from the fast reaction scheme, as reported by Stone and Marletta. Here the reaction is dependent upon the binding of NO to an unidentified non-heme site on the protein. Rates used directly from Stone and Marletta,1996, Biochemistry, 35(4):1093-1099. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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