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Molecule Parameter List for sGCslow | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| sGCslow participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | sGC_Stone_
Marletta | 15 | Pathway |
sGC | | This features the two step binding of NO to soluble Guanylyl Cyclase as proposed by Stone JR, Marletta MA. Biochemistry (1996) 35(4):1093-9. There is a fast step binding scheme and a slow step binding scheme. The difference lies in the binding of a NO to a non-heme site on sGC, which may not necessarily be the same site of binding during the initial binding. The rates have been directly used from their models |
sGCslow acting as a Molecule in sGC_Stone_Marletta Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | sGCslow | sGC_Stone_
Marletta
Accession No. : 15 | sGC
Pathway No. : 69 | 3 | 0.0016667 | No | | This is the slow reaction process of the binding of NO to sGC. we can notice the binding of another NO in the third reaction step to a non-heme site, which then converts to the 5-coordinate complex. this binding of another NO to an non-heme site is characteristic of the slow binding process of NO to sGC.(Stone and Marletta, 1996,35(4);1093-1099) Concentration 3 uM assumed on the basis of reported data (Kuroda et al., J.Neurosci., 2001, 21(15): 5693-5702 ; Ariano et al., PNAS, 1982, 79:1316-1320.) |
sGCslow acting as a Substrate in a reaction in sGC_Stone_Marletta Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | NO_bind_sGCslow | sGC_Stone_
Marletta
Accession No. : 15 | sGC
Pathway No. : 69 | 700
(uM^-1 s^-1) | 800
(s^-1) | Kd(bf) = 1.1429(uM) | - | Substrate
NO
sGCslow
Product
NO.sGCslow
| | This is the slow binding of NO to sGC, as reported by Stone and Marletta,1996, Biochemistry, 35(4):1093-1099.The rates shown have been used directly from their data from stopped flow kinetics. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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