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Molecule Parameter List for PDE | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| PDE participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | Kuroda_GC | 18 | Pathway |
SGC | | This model of sGC is based on the paper by Kuroda S. et al. J Neurosci. (2001) 21(15):5693-702. This models features the activation of sGC by NO, synthesis of cGMP, activity of PKG and PP2A in the synapse. The rates and concentrations have been taken from published literature. |
PDE acting as a Molecule in Kuroda_GC Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | PDE | Kuroda_GC
Accession No. : 18 | SGC
Pathway No. : 88 | 5 | 0.0016667 | No | | PhophoDiesterase ... Degrades cGMP to 5'GMP ... Conc Initially used from Kotera et al.,1997, Eur J Biochem, 249:434-442. |
PDE acting as an Enzyme in Kuroda_GC Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PDE /
kenz
| Kuroda_GC
Accession No. : 18 | SGC
Pathway No. : 88 | 2 | 3.87 | 4 | explicit E-S complex | Substrate
cGMP
Product
5prime_GMP
| | Km - 2 Vmax - 3.87 Thru personal Correspondence with Shinya Kuroda... rates initially from Turko et al., 1998, Biochem J, 329, 505-510 .. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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