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Molecule Parameter List for PP2A

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PP2A participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
Kuroda_GC18Pathway
SGC 
This model of sGC is based on the paper by Kuroda S. et al. J Neurosci. (2001) 21(15):5693-702. This models features the activation of sGC by NO, synthesis of cGMP, activity of PKG and PP2A in the synapse. The rates and concentrations have been taken from published literature.

PP2A acting as a Molecule in  
Kuroda_GC Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PP2AKuroda_GC
Accession No. : 18
SGC
Pathway No. : 88
2.70.0016667No
conc from Mumby et al., 1985, J Biol Chem, 260:13763-13770.

PP2A acting as a Substrate in a reaction in  
Kuroda_GC Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
PP2AbindGsub*Kuroda_GC
Accession No. : 18
SGC
Pathway No. : 88
1
(uM^-1 s^-1)
0.27
(s^-1)
Kd(bf) = 0.27(uM)-Substrate
Gsub*
PP2A

Product
PP2A_Gsub*
Kd - 0.27 uM Shinya Kuroda, J.Neurosci, 2001, 21(15):5693-5702.



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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