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Molecule Parameter List for TrKB

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
TrKB participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000021

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
BDNF_Receptor86Network
Shared_Object_BDNF_Receptor TrKB_mod PI3K_mod 
BDNF recetor signaling is one of the sub-model in BDNF signaling cascade. BDNF activates TrKB, leading to the stimulation of PI3K and formation of PIP3.

TrKB acting as a Molecule in  
BDNF_Receptor Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
TrKBBDNF_Receptor
Accession No. : 86
TrKB_mod
Pathway No. : 1083
0.25999.97No

TrKB acting as a Substrate in a reaction in  
BDNF_Receptor Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
 NameAccession NamePathway NameKfKbKdtauReagents
1Dimeriz_TrKBBDNF_Receptor
Accession No. : 86
TrKB_mod
Pathway No. : 1083
1
(uM^-1 s^-1)
0.02
(s^-1)
Kd(bf) = 0.02(uM)-Substrate
BDNF_TrkB_clx
TrKB

Product
BDNF_TrkB2_clx
2Ligand_bindingBDNF_Receptor
Accession No. : 86
TrKB_mod
Pathway No. : 1083
1.0001
(uM^-1 s^-1)
0.05
(s^-1)
Kd(bf) = 0.05(uM)-Substrate
BDNF
TrKB

Product
BDNF_TrkB_clx

TrKB acting as a Product in a reaction in  
BDNF_Receptor Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
LR_cyclingBDNF_Receptor
Accession No. : 86
TrKB_mod
Pathway No. : 1083
0.001
(s^-1)
0.001
(s^-1)
Keq = 1(uM)500secSubstrate
  • Int_BDNF_
    TrKB2*_clx


    Product
    TrKB



  • Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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