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Enzyme List for pathway MAPK (Pathway Number 139) in Accession MAPK_osc (Accession Number 27) |
Entries are grouped according to Pathway Number and they are alternately color coded using  and  color.Further ordering can be done according to header.   arrow indicates that ordering is done according to ascending or descending order. |
| Enzyme Molecule / Enzyme Activity | Pathway Name / Pathway No. | Km (uM) | kcat (s^-1) | Ratio (k2/k3) | Enzyme Type | Reagents | ||
| 1 | int1 / 2 | MAPK Pathway No. 139 | 0.008 | 0.25 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | Substrate: MKKK-P Product : MKKK | |
| Km is 8nM and Vmax is 0.25nM.s-1 from Kholodenko, 2000. | ||||||||
| 2 | MKKK-P / 3 | MAPK Pathway No. 139 | 0.0150001 | 0.025 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | Substrate: MKK Product : MKK-P | |
| Km is 15 nM and Vmax is 0.025s-1 from Kholodenko, 2000 | ||||||||
| 3 | MKKK-P / 4 | MAPK Pathway No. 139 | 0.0150001 | 0.025 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | Substrate: MKK-P Product : MKK-PP | |
| Km is 15nM and Vmax is 0.025s-1 from Kholodenko, 2000. | ||||||||
| 4 | int3 / 6 | MAPK Pathway No. 139 | 0.015 | 0.75 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | Substrate: MKK-P Product : MKK | |
| The Km is 15nM and the Vmax is 0.75nM.s-1 from Kholodenko 2000. | ||||||||
| 5 | int5 / 10 | MAPK Pathway No. 139 | 0.0149997 | 0.5 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | Substrate: MAPK-P Product : MAPK | |
| The Km is 15nM and Vmax is 0.5nM.s-1 from Kholodenko, 2000 | ||||||||
| 6 | int2 / 5 | MAPK Pathway No. 139 | 0.015 | 0.75 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | Substrate: MKK-PP Product : MKK-P | |
| The Km is 15nM and Vmax is 0.75nM.s-1 from Kholodenko, 2000 | ||||||||
| 7 | int4 / 9 | MAPK Pathway No. 139 | 0.0149997 | 0.5 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | Substrate: MAPK-PP Product : MAPK-P | |
| The Km is 15nM and Vmax is 0.5nM.s-1 from Kholodenko, 2000 | ||||||||
| 8 | Ras-MKKKK / 1 | MAPK Pathway No. 139 | 0.01 | 2.5 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | Substrate: MKKK Product : MKKK-P | |
| The Km is 10nM and Vmax is 2.5nM sec^-1. We assume that there is 1 nM of the Ras-MKKKK. From Kholodenko, 2000. If the enzymes are not flagged as Available, then this Km should be set to 0.1 to obtain oscillations. | ||||||||
| 9 | MKK-PP / 7 | MAPK Pathway No. 139 | 0.0150001 | 0.025 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | Substrate: MAPK Product : MAPK-P | |
| The Km is 15nM which is 0.015uM Vmax is 0.025s-1 from Kholodenko, 2000. | ||||||||
| 10 | MKK-PP / 8 | MAPK Pathway No. 139 | 0.0150001 | 0.025 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | Substrate: MAPK-P Product : MAPK-PP | |
| The Km is 15nM which is 0.015uM and Vmax is 0.025s-1 from Kholodenko, 2000 | ||||||||