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Enzyme List for pathway PP2B (Pathway Number 248) in Accession AMPAR_traff_model1 (Accession Number 60)

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  Enzyme Molecule /

 Enzyme Activity
Pathway Name / 
Pathway No.
Km
(uM)
kcat
(s^-1)
Ratio
(k2/k3)
Enzyme TypeReagents
1 CaNAB-Ca4 /
  • dephosph_
    inhib1_noCaM
  • PP2B

    Pathway No. 248
    4.970790.0344explicit E-S complexSubstrate: 
    I1*
    Product : 
    I1
      The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
    2 CaNAB-Ca4 /
  • dephosph_
    inhib1_noCaM_
    PSD
  • PP2B

    Pathway No. 248
    4.970710.0344explicit E-S complexSubstrate: 
    I1*
    Product : 
    I1
      The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
    3 CaM_Ca_n-CaNAB /
  • dephosph_
    neurogranin
  • PP2B

    Pathway No. 248
    10.0120.673.98507explicit E-S complexSubstrate: 
    neurogranin*
    Product : 
    neurogranin
      From Seki et al ABB 316(2):673-679
    4 CaM_Ca_n-CaNAB /
    dephosph_inhib1
    PP2B

    Pathway No. 248
    4.970790.344explicit E-S complexSubstrate: 
    I1*
    Product : 
    I1
    5 CaM_Ca_n-CaNAB /
    dephosph-PP1-I*
    PP2B

    Pathway No. 248
    4.970790.344explicit E-S complexSubstrate: 
    PP1-I1*
    Product : 
    PP1-I1
    6 CaM_Ca_n-CaNAB /
  • dephosph_
    inhib1_PSD
  • PP2B

    Pathway No. 248
    4.970710.344explicit E-S complexSubstrate: 
    I1*
    Product : 
    I1
    7 CaM_Ca_n-CaNAB /

  • dephosph-PP1-I*_
    PSD
  • PP2B

    Pathway No. 248
    4.970710.344explicit E-S complexSubstrate: 
    PP1-I1*
    Product : 
    PP1-I1
    8 CaM_Ca_n-CaNAB /
    PP2B[17]
    PP2B

    Pathway No. 248
    4.9706124explicit E-S complexSubstrate: 
    A845*_B
    Product : 
    A_B
    9 CaM_Ca_n-CaNAB /
    PP2B[18]
    PP2B

    Pathway No. 248
    4.9706124explicit E-S complexSubstrate: 
    A831*845*_B
    Product : 
    A831*_B
    10 CaM_Ca_n-CaNAB /
    PP2B[19]
    PP2B

    Pathway No. 248
    4.9706124explicit E-S complexSubstrate: 
    A845*_B831*
    Product : 
    A_B831*
    11 CaM_Ca_n-CaNAB /
    PP2B[20]
    PP2B

    Pathway No. 248
    4.9706124explicit E-S complexSubstrate: 
    A831*845*_B831*
    Product : 
    A831*_B831*
    12 CaM_Ca_n-CaNAB /
    PP2B[21]
    PP2B

    Pathway No. 248
    4.9706124explicit E-S complexSubstrate: 
    A_B845*
    Product : 
    A_B
    13 CaM_Ca_n-CaNAB /
    PP2B[22]
    PP2B

    Pathway No. 248
    4.9706124explicit E-S complexSubstrate: 
    A831*_B845*
    Product : 
    A831*_B
    14 CaM_Ca_n-CaNAB /
    PP2B[23]
    PP2B

    Pathway No. 248
    4.9706124explicit E-S complexSubstrate: 
    A_B831*845*
    Product : 
    A_B831*
    15 CaM_Ca_n-CaNAB /
    PP2B[24]
    PP2B

    Pathway No. 248
    4.9706124explicit E-S complexSubstrate: 
    A831*_B831*845*
    Product : 
    A831*_B831*
    16 CaM_Ca_n-CaNAB /
    PP2B[25]
    PP2B

    Pathway No. 248
    4.9706124explicit E-S complexSubstrate: 
    A845*_B845*
    Product : 
    A_B845*
    17 CaM_Ca_n-CaNAB /
    PP2B[26]
    PP2B

    Pathway No. 248
    4.9706124explicit E-S complexSubstrate: 
    A831*845*_B845*
    Product : 
    A831*_B845*
    18 CaM_Ca_n-CaNAB /
    PP2B[27]
    PP2B

    Pathway No. 248
    4.9706124explicit E-S complexSubstrate: 
    A845*_B831*845*
    Product : 
    A_B831*845*
    19 CaM_Ca_n-CaNAB /
    PP2B[28]
    PP2B

    Pathway No. 248
    4.9706124explicit E-S complexSubstrate: 
    A835*845*_
    B835*845*

    Product : 
    A831*_B831*845*
    20 CaM_Ca_n-CaNAB /
    PP2B[29]
    PP2B

    Pathway No. 248
    4.9706124explicit E-S complexSubstrate: 
    A845*_B845*
    Product : 
    A845*_B

     
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