NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By


 
Result: 1 - 20 of 35 rows are displayed Previous of 2  Next

Enzyme List for pathway PKA (Pathway Number 250) in Accession AMPAR_traff_model1 (Accession Number 60)

Entries are grouped according to Pathway Number and they are alternately color coded using  and   color.
Further ordering can be done according to header.
arrow indicates that ordering is done according to ascending or descending order.
  Enzyme Molecule /

 Enzyme Activity
Pathway Name / 
Pathway No.
Km
(uM)
kcat
(s^-1)
Ratio
(k2/k3)
Enzyme TypeReagents
1 PKA-active /
phosph-PDE
PKA

Pathway No. 250
7.5000894explicit E-S complexSubstrate: 
cAMP-PDE
Product : 
cAMP-PDE*
  Same rates as PKA-phosph-I1
2 PKA-active /
PKA-phosph-I1
PKA

Pathway No. 250
7.5000894explicit E-S complexSubstrate: 
I1
Product : 
I1*
  #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
3 PKA-active /
  • PKA-phosph-I1_
    PSD
  • PKA

    Pathway No. 250
    7.5000894explicit E-S complexSubstrate: 
    I1
    Product : 
    I1*
    4 PKA-active /
    PKA[17]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A_B
    Product : 
    A845*_B
    5 PKA-active /
    PKA[16]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A831*_B
    Product : 
    A831*845*_B
    6 PKA-active /
    PKA[18]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A_B831*
    Product : 
    A845*_B831*
    7 PKA-active /
    PKA[19]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A831*_B831*
    Product : 
    A831*845*_B831*
    8 PKA-active /
    PKA[20]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A_B
    Product : 
    A_B845*
    9 PKA-active /
    PKA[21]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A831*_B
    Product : 
    A831*_B845*
    10 PKA-active /
    PKA[22]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A_B831*
    Product : 
    A_B831*845*
    11 PKA-active /
    PKA[23]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A831*_B831*
    Product : 
    A831*_B831*845*
    12 PKA-active /
    PKA[24]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A_B845*
    Product : 
    A845*_B845*
    13 PKA-active /
    PKA[25]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A831*_B845*
    Product : 
    A831*845*_B845*
    14 PKA-active /
    PKA[26]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A_B831*845*
    Product : 
    A845*_B831*845*
    15 PKA-active /
    PKA[27]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A831*_B831*845*
    Product : 
    A835*845*_
    B835*845*

    16 PKA-active /
    PKA[28]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A845*_B
    Product : 
    A845*_B845*
    17 PKA-active /
    PKA[29]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A831*845*_B
    Product : 
    A831*845*_B845*
    18 PKA-active /
    PKA[30]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A845*_B831*
    Product : 
    A845*_B831*845*
    19 PKA-active /
    PKA[31]
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A831*845*_B831*
    Product : 
    A835*845*_
    B835*845*

    20 PKA-active /
    PKA
    PKA

    Pathway No. 250
    7.5002164explicit E-S complexSubstrate: 
    A_B845*
    Product : 
    A845*_B845*

     
    Result: 1 - 20 of 35 rows are displayed Previous of 2  Next



    Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.