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Enzyme List for pathway PDGFR (Pathway Number 38) in Accession mkp1_feedback_effects (Accession Number 4)

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  Enzyme Molecule /

 Enzyme Activity
Pathway Name / 
Pathway No.
Enzyme TypeReagents

Pathway No. 38
0.8333330.054explicit E-S complexSubstrate: 
Product : 
  Rates from Okada et al JBC 270:35 pp 20737 1995 Km = 0.70 to 0.85 uM, Vmax = 4.4 to 5.0 pmol/min. Unfortunately the amount of enzyme is not known, the prep is only partially purified. Tau phosph is max within 30 sec, falls back within 20 min. Ref: Sasaoka et al JBC 269:51 32621 1994. Use k3 = 0.1 based on this tau. 27 Apr 2001: Lowered k3 to 0.05 to fix conc-effect of SHC phosph by PDGF. This gives results for downstream effects in agreement with other papers, e.g., the Brondello papers.

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