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Molecule List for pathway Gs (Pathway Number 137) in Accession cAMP_pathway (Accession Number 25)
| Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.|
arrow indicates that ordering is done according to ascending or descending order.
The entries are grouped according to Pathway Number and are alternately color coded using and color.
|Buffered||Sum Total Of|
|1|| Gbg||Network||0||1000||No||- |
| || The Gbetagamma dimer.|
|2|| GDP.Ga||Network||0||1000||No||- |
| || The inactive GDP-bound form of Gs alpha.|
|3|| GDP.Gabc||Network||1||1000||No||- |
| || The resting state of Gs: GDP bound to trimer. From Pang and Sternweis JBC 265:30 18707-12 1990 we get conc est 1.6 uM to 0.8 uM. We'll use 1 uM. |
|4|| L||Network||0||1000||Yes||- |
| || This ligand could be any of several which bind to the beta adrenergic receptor and other G-protein coupled receptors which activate AC. For the sake of argument, call it isoproterenol.|
|5|| L.R||Network||0||1000||No||- |
| || Ligand.Receptor complex |
|6|| L.R.GDP.Gabc||Network||0||1000||No||- |
| || This is the ternary complex, where all the action happens. There are actually a lot more steps here, including a final step where the GTP binds the L.R.Ga complex and causes the release of GTP.Ga from the L.R. For simplicity this is excluded.|
|7|| R||Network||0.0833||1000||No||- |
| || A typical number of receptors per cell is about 50000.|
|8|| R.GDP.Gabc||Network||0||1000||No||- |
| || Fraction of R.GDP.Gabc is about 50% of total R, from Fay et al. Biochemistry 30:5066-5075(1991) Since this is not the same receptor, this value is a bit uncertain. |
|Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR |
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