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Result: 1 - 3 of 3 rows are displayed

Reaction List for pathway PP2B (Pathway Number 238) in Accession AMPAR_traff_model0 (Accession Number 59)

Entries are grouped according to Pathway Number and they are alternately color coded using  and  color.
Further ordering can be done to the table header.  indicates that ordering is done according to ascending or descending order.
Keq is calculated only for first order reactions.
Kd is calculated only for second order reactions. [nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules]
  Reaction
Name
Pathway Name / 
Pathway No.
KfKbKdtauReagents
1 
  • Ca-bind-CaNAB-Ca
    2
  • PP2B

    Pathway No. 238
    3.6001
    (uM^-2 s^-1)
    1
    (s^-1)
    Kd(af) = 0.527(uM)-  Substrate:
     Ca
     Ca
     CaNAB-Ca2

     Products:
     CaNAB-Ca4
      This process is probably much more complicated and involves CaM. However, as I can't find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11
    2 Ca-bind-CaNABPP2B

    Pathway No. 238
    10008
    (uM^-2 s^-1)
    1
    (s^-1)
    Kd(af) = 0.01(uM)-  Substrate:
     CaNAB
     Ca
     Ca

     Products:
     CaNAB-Ca2
      going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1 
    3 
  • CaMCa4-bind-CaNA
    B
  • PP2B

    Pathway No. 238
    599.994
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.0017(uM)-  Substrate:
     CaM-Ca4
     CaNAB-Ca4

     Products:
     CaM_Ca_n-CaNAB

     
    Result: 1 - 3 of 3 rows are displayed



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