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Accession Type:
Network
Mammalian_cell_
cycle
Growth
 Molecule
 Enzyme
 Reaction
CELLDIV
Rb_grp
IE_GRP
CycB_Grp
Cdc20_Grp
Cdh1_grp
E2F
CycA_Grp
CycE_grp
Early_Response_
Genes
Delayed_
Response_Genes
CycD_Grp

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Reaction List for pathway Growth (Pathway Number 1069)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 H1kf
(uM^-4 s^-1)
125
(s^-1)
--Rb_dup
Rb_dup
Rb_dup
Rb_dup
Heaviside_inh
Heaviside_mid
  This reaction approximates the Heaviside function. What it does is to present a high-order dependence on Rb_P, such that when Rb_P is about 0.8 of the total It is supposed to be 1 if Rb_hypo <= 0.8 Rb_tot. Here we have Rb_P = Rb_tot - Rb_hypo, so we want the outcome to be 1 if Rb_P > 0.2 We use a 4th order step to get a sharper transition. Use a sumtotal so that Rb_P itself is not affected. 29 March 2005. Now this is part of a 2-step heaviside function, perhaps more biologically motivated. Also the input is Rb. 18 Apr 2005. Speeded up 10 fold. Also note that the critical amount of Rb is Rb/Rbtot. Since Rbtot = 10, the Kd should be 8, not 0.8.
2 k28kf
(s^-1)
0
(s^-1)
--GM
degraded
  k28 = 0.2


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