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Response_Genes |
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Enzyme List for pathway Rb_grp (Pathway Number 1071) | | Molecule Name/
Site Name | Km (uM) | kcat (1/s) | Ratio
(k2/k3) | Enzyme Type | Substrate | Product |
| 1 |
Enzyme Activity:
k19
Enzyme Molecule:
PP1A | 100 | 2000 | 4 | explicit E-S complex | Rb_P
| Rb
| | | This is part of Eqn 20. k19 = 20. It is meant to represent a dephosph step of Rb_p. rate is k19*PP1A. rate in MM form is kcat * PP1A * Rb_P / (Km + Rb_P) Assume Km << Rb_P. To do so, Km = 0.01 Then kcat = k19. 7 Apr 2005. Actually should include substrate term. Take Km = 10 >> sub. Then kcat = Km * k19 = 200 18 April. Actually substrate levels are near 10. So need to scale up. Km = 100, kcat = Km * k19 = 2000 |
| 2 |
Enzyme Activity:
k19_prime
Enzyme Molecule:
PP1 | 99.9992 | 0.1 | 4 | explicit E-S complex | Rb_P
| Rb
| | | k19_prime is actually zero, but I do not want NaNs (numerical errors due to divide-by-zero) so I set kcat to a very small value. 7 Apr 2005. Same reasoning, now set Km to 10. |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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