NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Accession Type:
Network
Mammalian_cell_
cycle
Growth
CELLDIV
Rb_grp
IE_GRP
CycB_Grp
Cdc20_Grp
Cdh1_grp
E2F
 Molecule
 Reaction
CycA_Grp
CycE_grp
Early_Response_
Genes
Delayed_
Response_Genes
CycD_Grp

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Reaction List for pathway E2F (Pathway Number 1076)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 k22_23_primekf
(s^-1)
0.005
(s^-1)
Keq = 0.005(uM)0.995secE2FAP
E2FA
  k22 is the forward rate of 1 k23_prime is the backward rate of 0.005
2 k22_23_prime.Rbkf
(s^-1)
0.005
(s^-1)
Keq = 0.005(uM)0.995secE2FAP.Rb
E2FA.Rb
  k22 is the forward rate of 1 k23_prime is the backward rate of 0.005
3 k26kf
(uM^-1 s^-1)
200
(s^-1)
Kd(bf) = 20.0001(uM)-Rb
E2FA
E2FA.Rb
  k26 = 10, k26r =200 Unless k26 = 10000. There is a period in the paper but it may be a typo. The form of the equation is complex, but if k26 is large then there is more E2F:Rb, so that is the forward reaction here.
4 k26_Pkf
(uM^-1 s^-1)
200
(s^-1)
Kd(bf) = 20.0001(uM)-Rb
E2FAP
E2FAP.Rb
  Same as k26, but acting on the phosph form.


Pathway Details   Molecule List  Enzyme List  Reaction List  


Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.