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Accession Type:
Network
RanGTPase
Shared_Object_
RanGTPase
Nucleus
Cytoplasm
 Molecule
 Enzyme
 Reaction

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Reaction List for pathway Cytoplasm (Pathway Number 306)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 NTF2_bindingkf
(uM^-1 s^-1)		0.1
(s^-1)		Kd(bf) = 0.1(uM)-NTF2
  • GDP.Ran-cytoplas
    mic
    		• NTF2-GDP.Ran
      Binding of NTF2 to cytoplasmic fraction of GDP.Ran Kd = 100 nM Catherine Chaillan-Huntington et al (2000) J.Biol.Chem. 275(8):5874-5879. call /kinetics/Cytoplasm/RanGTP_binding/notes LOAD Binding of cytoplasmic fraction of RanGTP to RanBP1 Kf = 3.0e+05 /M/sec = 0.3 /uM/sec Kb = 4.0e-04 /sec Carolina I. Villa Braslavsky et al (2000) Biochemistry 39(38):11629-11639. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100
    2 NTF2_
    dissociation    		kf
    (s^-1)    		0
    (#^-1 s^-1)    		Not applicable**-NTF2-GDP.Ran
    		NTF2
    GDP.Ran-nuclear
      Approximation of rates to match the kinetics described by Gorlich D et al (2003) EMBO J 22(5):1088-1100
    3 RanGTP_bindingkf
    (uM^-1 s^-1)    		0.0004
    (s^-1)    		Kd(bf) = 0(uM)-
  • GTP.Ran-cytoplas
    mic
    RanBP1
    		• RanBP1.RanGTP


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