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Reaction List for pathway condorelliGCmod (Pathway Number 89) | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |   | Name | Kf | Kb | Kd | tau | Substrate | Product | 1 |
dissoNO | kf (s^-1) | 0 (uM^-1 s^-1) | - | - | NO_sGCfull_act
| NO sGC_basal
| | This is a modification by Condorelli et al., 2001, Biophys J of the recent binding scheme of Zhao et al., to include the NO dissociation from fully active complex of sGC... The dissociation is characterised by the respective first order rate constants depicted in the model... Rates are obtained at 4C... | 2 |
NObind_sGC | kf (uM^-1 s^-1) | 350 (s^-1) | Kd(bf) = 0.3571(uM) | - | sGC_basal NO
| NO_sGCpart_act
| | Rates at 4C... used directly from paper by Condorelli P, 2001, Biophysical J, 80:2110-2119, which in turn have been obtained mainly from Zhao et al., 1999, PNAS,96:14753-14758. | 3 |
NOdepPway | kf (uM^-1 s^-1) | 0 (s^-1) | - | - | NO_sGCpart_act NO_a
| NO_sGCfull_act
| | Rates from stopped flow experiments performed at 4C from Zhao et al., 1999, PNAS,96:14753-14758. Same rates used by Condorelli P, for his simulations... | 4 |
NOindePway | kf (s^-1) | 0.014 (s^-1) | Keq = 0.2299(uM) | 13.351sec | NO_sGCpart_act
| NO_sGCfull_act
| | Rates used directly from Condorelli et al., 2001, Biophysical J, 80:2110-2119 .... Rates originally from Zhao et al., 1999, PNAS, 96:14753-14758 from stopped flow spectroscopy experiments performed at 4C. |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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