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Molecule List for CamKII

Default ordering is done according to Molecule Name. Table headers can be used for changing the default ordering.

arrow indicates that ordering is done according to ascending or descending order.
The entries are grouped according to Pathway Number and are alternately color coded using

and

color.

	Name	Accession Name / Accession No.	Pathway Name / Pathway No.	Accession Type	Initial Conc. (uM)	Volume (fL)	Buffered	Sum Total Of
1	CaMKIII	syn_prot_ composite Accession No. 109	CaMKIII_g Pathway No. 1145	Pathway	0.058	0	No	-
2	aCaMKIII	syn_prot_ composite Accession No. 109	CaMKIII_g Pathway No. 1145	Pathway	0	0	No	-
3	CaMKIII	syn_CaMKIII Accession No. 114	CaMKIII_g Pathway No. 1159	Pathway	0.0584	0	No	-
4	aCaMKIII	syn_CaMKIII Accession No. 114	CaMKIII_g Pathway No. 1159	Pathway	0	0	No	-
5	CaMKII	Synaptic_ Network Accession No. 16	CaMKII Pathway No. 80	Network	70	1000	No	-
	Huge concentration of CaMKII. In PSD it is 20-40% of protein, so we assume it is around 2.5% of protein in spine as a whole. This level is so high it is unlikely to matter much if we are off a bit. This comes to about 70 uM. Seen the review: Hanson and Schulman 1992 Ann. Rev. Biuochem 60:559-601
6	CaMKII-CaM	Synaptic_ Network Accession No. 16	CaMKII Pathway No. 80	Network	0	1000	No	-
	This is the regular, CaM-activated form of CaMKII. See the review Hanson and Schulman 1992 Ann. Rev. Biochem 60:559-601
7	CaMKII-thr286*-C aM	Synaptic_ Network Accession No. 16	CaMKII Pathway No. 80	Network	0	1000	No	-
	From Hanson and Schulman, the thr286 is responsible for autonomous activation of CaMKII.
8	CaMKII***	Synaptic_ Network Accession No. 16	CaMKII Pathway No. 80	Network	0	1000	No	-
	From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.
9	CaMKII-thr286	Synaptic_ Network Accession No. 16	CaMKII Pathway No. 80	Network	0	1000	No	-
	The threonine-286 phosphorylated form of CaMKII. It is likely to be a short-lived intermediate, since it will be phosphorylated further as soon as the CAM falls off.
10	total-CaMKII	Synaptic_ Network Accession No. 16	CaMKII Pathway No. 80	Network	70	1000	Yes	-
	This pool is purely here to provide a single, fixed number, which is the total amount of CaMKII. This is used by the autophosphorylation steps to scale down the rates so that the autophosphorylation reactions are independent of CaMKII levels.
11	tot_CaM_CaMKII	Synaptic_ Network Accession No. 16	CaMKII Pathway No. 80	Network	0	1000	No