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Molecule Parameter List for L-Arg | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| L-Arg participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | NOS_Iwanaga | 11 | Pathway |
NOS | | This model is based on Iwanaga T et al. Biochemistry (1999) 38(50):16629-35.The model features the catalytic activity of neuronal Nitric Oxide Synthase expressed in Escherichia coli in a four step reaction mechanism. The rates found in the model are used directly from their paper and have been determined from experiments performed at 25 C. |
L-Arg acting as a Molecule in NOS_Iwanaga Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | L-Arg | NOS_Iwanaga
Accession No. : 11 | NOS
Pathway No. : 65 | 100 | 0.0016667 | No | | The intracellular concentrations are atleast 100 uM. Substrate for nNOS. |
L-Arg acting as a Substrate in a reaction in NOS_Iwanaga Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | nNOSbindArg | NOS_Iwanaga
Accession No. : 11 | NOS
Pathway No. : 65 | 0.5
(uM^-1 s^-1) | 81
(s^-1) | Kd(bf) = 162(uM) | - | Substrate
Ca-CaM_nNOS
L-Arg
Product
nNOS.arg
| | From Stuehr et al., Biochem,1999,38(38):12446-12451. Steuhr et al., from stopped flow expts of sub binding to nNOS report 0.5 (k-1) and 81 (k2). Rates used straight from results. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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