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Molecule Parameter List for nNOS.Cit+NO | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | NOS_Iwanaga | 11 | Pathway |
NOS | | This model is based on Iwanaga T et al. Biochemistry (1999) 38(50):16629-35.The model features the catalytic activity of neuronal Nitric Oxide Synthase expressed in Escherichia coli in a four step reaction mechanism. The rates found in the model are used directly from their paper and have been determined from experiments performed at 25 C. |
nNOS.Cit+NO acting as a Molecule in NOS_Iwanaga Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | nNOS.Cit+NO | NOS_Iwanaga
Accession No. : 11 | NOS
Pathway No. : 65 | 0 | 0.0016667 | No | | Citrulline and NO basically dissociate from the NOS enzyme complex, and this is the NOS bound with Citrulline and NO, and they dissociate in the subsequent step. |
nNOS.Cit+NO acting as a Substrate in a reaction in NOS_Iwanaga Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | k4 | NOS_Iwanaga
Accession No. : 11 | NOS
Pathway No. : 65 | 2.7
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate
nNOS.Cit+NO
Product
Cit
NO
| | Rate from Biochem., 1999, 38(50), 16629-16635., from rapid quenching expts at 25 C >>>>>> 2.7 +/- 0.3 |
nNOS.Cit+NO acting as a Product in a reaction in NOS_Iwanaga Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | k3 | NOS_Iwanaga
Accession No. : 11 | NOS
Pathway No. : 65 | 19
(s^-1) | 0
(s^-1) | - | - | Substrate
nNOS.OH.Arg
Product
nNOS.Cit+NO
| | Rate from Biochem., 1999, 38(50), 16629-16635. Obtained from rapid queching expts at 25 C >>>>>> 19 +/- 3.0 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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