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Molecule Parameter List for FeIII | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | Stuehr_NOS | 12 | Pathway |
NOS | | This is a model of neuronal Nitric Oxide Synthase expressed in Escherichia coli based on Santolini J. et al. J Biol Chem. (2001) 276(2):1233-43. The rates have been converted by 2x for every 10 degrees C. The original temperature was 10 degree C, cell temperature is assumed 30 degree C, so the conversion factor is 4. |
FeIII acting as a Molecule in Stuehr_NOS Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | FeIII | Stuehr_NOS
Accession No. : 12 | NOS
Pathway No. : 66 | 0 | 0.0016667 | No | | |
FeIII acting as a Substrate in a reaction in Stuehr_NOS Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | k1 | Stuehr_NOS
Accession No. : 12 | NOS
Pathway No. : 66 | 10.4
(s^-1) | 0
(s^-1) | - | - | Substrate
FeIII
Product
FeII
| | Rates from Stuehr et al., 2001, JBC, 276(2):1233-1243. All the rates increased by 2X for every 10 C rise to get it to the cell temp.. (thru personal correspondence) kf -- 10.4 |
FeIII acting as a Product in a reaction in Stuehr_NOS Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | arg_bind_nNOS | Stuehr_NOS
Accession No. : 12 | NOS
Pathway No. : 66 | 0.5
(uM^-1 s^-1) | 81
(s^-1) | Kd(bf) = 162(uM) | - | Substrate
Ca-CaM_nNOS
L-Arg
Product
FeIII
| | | From Stuehr et al., Biochem, 1999, 38(38):12446-12451. Rates used as it is from their results. | | 2 | kF | Stuehr_NOS
Accession No. : 12 | NOS
Pathway No. : 66 | 20
(s^-1) | 0
(s^-1) | - | - | Substrate
FeIII_NO
Product
FeIII
| | | Rates from Stuehr et al., JBC, 2001; 276(2): 1233-1243., rates increased by 2X for every 10 C rise, to get it ot the cell temp..(thru personal correspondence) kf -- 20 | | 3 | k10 | Stuehr_NOS
Accession No. : 12 | NOS
Pathway No. : 66 | 1.2
(uM^-1 s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate
FeII_NO
O2
Product
FeIII
NO3
| | | The rates were obtained from Stuehr et al, JBC 2001, 276(2): 1233-1243.... The rates are multiplied by 2X for every 10 C rise, to get it to the cell temp. kf -- 0.0052 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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