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Molecule Parameter List for NO.sGCfast | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | sGC_Stone_
Marletta | 15 | Pathway |
sGC | | This features the two step binding of NO to soluble Guanylyl Cyclase as proposed by Stone JR, Marletta MA. Biochemistry (1996) 35(4):1093-9. There is a fast step binding scheme and a slow step binding scheme. The difference lies in the binding of a NO to a non-heme site on sGC, which may not necessarily be the same site of binding during the initial binding. The rates have been directly used from their models |
NO.sGCfast acting as a Molecule in sGC_Stone_Marletta Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | NO.sGCfast | sGC_Stone_
Marletta
Accession No. : 15 | sGC
Pathway No. : 69 | 0 | 0.0016667 | No | | |
NO.sGCfast acting as a Substrate in a reaction in sGC_Stone_Marletta Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | form_6coord | sGC_Stone_
Marletta
Accession No. : 15 | sGC
Pathway No. : 69 | 850
(s^-1) | 0
(s^-1) | - | - | Substrate
NO.sGCfast
Product
NO.SGC_6coord
| | Rates used directly from Stone and Marletta,1996,Biochemistry, 35(4):1093-1099. |
NO.sGCfast acting as a Product in a reaction in sGC_Stone_Marletta Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | NO_bind_sGCfast | sGC_Stone_
Marletta
Accession No. : 15 | sGC
Pathway No. : 69 | 700
(uM^-1 s^-1) | 800
(s^-1) | Kd(bf) = 1.1429(uM) | - | Substrate
NO
sGCfast
Product
NO.sGCfast
| | This is the fast binding of NO to sGC, subsequently activating it, as proposed by Stone and Marletta. Rates of these binding reactions used directly from Stone and Marletta,1996, Biochemistry, 35(4):1093-1099, based on whose paper this model is made. Rates obtained from stopped flow kinetics detailed in their paper. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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