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Molecule Parameter List for GC | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GC participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| Kuroda_GC | 18 | Pathway | SGC |
| This model of sGC is based on the paper by Kuroda S. et al. J Neurosci. (2001) 21(15):5693-702. This models features the activation of sGC by NO, synthesis of cGMP, activity of PKG and PP2A in the synapse. The rates and concentrations have been taken from published literature. | |||
GC acting as a Molecule in Kuroda_GC Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| GC | Kuroda_GC Accession No. : 18 | SGC Pathway No. : 88 | 3 | 0.0016667 | Yes | |
| Guanylyl Cyclase ... Intracellular concentration is around 3 uM, as sGC is enrcihed in the Purkinje cells (Shinya Kuroda, personal corresspondence).. Conc assumed on the basis of reported data in Ariano et al., 1982, PNAS,79:297-300. | ||||||
GC acting as a Substrate in a reaction in Kuroda_GC Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| NObindGC | Kuroda_GC Accession No. : 18 | SGC Pathway No. : 88 | 0.01 (uM^-1 s^-1) | 0.0025 (s^-1) | Kd(bf) = 0.25(uM) | - | Substrate GC NO Product NO_GC |
| Kd 250 nM (Stone and Marletta, 1996).. kf - 0.01 kb - 0.0025 Shinya Kuroda, J.Neurosci, 2001, 21(15):5693-5702 ... | |||||||