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Molecule Parameter List for PP1-I1* | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PP1-I1* participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 2 | 0 | 0 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| fig3_CaMKII | 2 | Network | Shared_Object_fig3_CaMKII, CaMKII, CaM, PP1, PP2B, PKA, AC |
| This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse. Demonstration script files for generating the figures in the paper, including figure 3, are available here. | |||
PP1-I1* acting as a Molecule in fig3_CaMKII Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| PP1-I1* | fig3_CaMKII Accession No. : 2 | PP1 Pathway No. : 15 | 0 | 1000 | No | |
PP1-I1* acting as a Substrate for an Enzyme in fig3_CaMKII Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | |
| 1 | CaM(Ca)n-CaNAB / dephosph-PP1-I* | fig3_CaMKII Accession No. : 2 | fig3_CaMKII Pathway No. : 12 | 4.97076 | 0.34 | 4 | explicit E-S complex | Substrate PP1-I1* Product PP1-I1 |
| 2 | PP2A / 1-I* | fig3_CaMKII Accession No. : 2 | fig3_CaMKII Pathway No. : 12 | 7.82828 | 6 | 4.16667 | explicit E-S complex | Substrate PP1-I1* Product PP1-I1 |
PP1-I1* acting as a Product in a reaction in fig3_CaMKII Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| Inact-PP1 | fig3_CaMKII Accession No. : 2 | PP1 Pathway No. : 15 | 499.98 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 0.0002(uM) | - | Substrate I1* PP1-active Product PP1-I1* |