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Molecule Parameter List for R2C2-cAMP2 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | fig3_CaMKII | 2 | Network |
Shared_Object_fig3_CaMKII, CaMKII, CaM,
PP1, PP2B, PKA,
AC | This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here. |
R2C2-cAMP2 acting as a Molecule in fig3_CaMKII Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | R2C2-cAMP2 | fig3_CaMKII
Accession No. : 2 | PKA
Pathway No. : 17 | 0 | 1000 | No | | R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with one molecule of cAMP bound to each of the B sites on the regulatory subunit. |
R2C2-cAMP2 acting as a Substrate in a reaction in fig3_CaMKII Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
R2C2-cAMP2 acting as a Product in a reaction in fig3_CaMKII Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | cAMP-bind-site-B
2 | fig3_CaMKII
Accession No. : 2 | PKA
Pathway No. : 17 | 54
(uM^-1 s^-1) | 33
(s^-1) | Kd(bf) = 0.6111(uM) | - | Substrate
R2C2-cAMP
cAMP
Product
R2C2-cAMP2
| Kf = 54 /sec/uM, Kb = 33 /sec; Same Km (1e-07M) assumed as site B1.
kf/kb = 0.7e-07M*1e06/(6e05^02) = 2e-13:2.77e-12 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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