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Molecule Parameter List for AC2* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | fig3_CaMKII | 2 | Network |
Shared_Object_fig3_CaMKII, CaMKII, CaM,
PP1, PP2B, PKA,
AC | This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here. |
AC2* acting as a Molecule in fig3_CaMKII Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | AC2* | fig3_CaMKII
Accession No. : 2 | AC
Pathway No. : 18 | 0 | 1000 | No | | |
AC2* acting as an Enzyme in fig3_CaMKII Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | AC2* /
kenz
| fig3_CaMKII
Accession No. : 2 | AC
Pathway No. : 18 | 20.1149 | 7 | 4 | Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S | Substrate
ATP
Product
cAMP
|
AC2* acting as a Product of an Enzyme in fig3_CaMKII Network
AC2* acting as a Substrate in a reaction in fig3_CaMKII Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | dephosph-AC2 | fig3_CaMKII
Accession No. : 2 | AC
Pathway No. : 18 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
AC2*
Product
AC2
| | 2 | Gs-bind-AC2* | fig3_CaMKII
Accession No. : 2 | AC
Pathway No. : 18 | 833.28
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.0012(uM) | - | Substrate
AC2*
Gs-alpha
Product
AC2*-Gs
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| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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