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Molecule Parameter List for PKC-active | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PKC-active participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 3 | 0 | 0 | 0 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| fig3_CaMKII | 2 | Network | Shared_Object_fig3_CaMKII, CaMKII, CaM, PP1, PP2B, PKA, AC |
| This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse. Demonstration script files for generating the figures in the paper, including figure 3, are available here. | |||
PKC-active acting as a Molecule in fig3_CaMKII Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| PKC-active | fig3_CaMKII Accession No. : 2 | fig3_CaMKII Pathway No. : 12 | 0.09 | 1000 | Yes | |
PKC-active acting as an Enzyme in fig3_CaMKII Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | |
| 1 | PKC-active / granin | fig3_CaMKII Accession No. : 2 | fig3_CaMKII Pathway No. : 12 | 28.6275 | 0.58 | 4.03448 | explicit E-S complex | Substrate neurogranin Product neurogranin* |
| 2 | PKC-active / M | fig3_CaMKII Accession No. : 2 | fig3_CaMKII Pathway No. : 12 | 28.5948 | 0.35 | 4 | explicit E-S complex | Substrate neurogranin-CaM Product CaM neurogranin* |
| 3 | PKC-active / phosph-AC2 | fig3_CaMKII Accession No. : 2 | fig3_CaMKII Pathway No. : 12 | 33.3333 | 4 | 4 | explicit E-S complex | Substrate AC2 Product AC2* |