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Molecule Parameter List for PKC-active

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKC-active participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1030000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig3_CaMKII2Network
Shared_Object_fig3_CaMKII,  CaMKII,  CaM,  
PP1,  PP2B,  PKA,  
AC 
This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here.

PKC-active acting as a Molecule in  fig3_CaMKII Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
PKC-activefig3_CaMKII
Accession No. : 2
  • Shared_Object_
    fig3_CaMKII
    Pathway No. : 12
    		• 0.091000Yes

    PKC-active acting as an Enzyme in      fig3_CaMKII Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PKC-active /
  • PKC-phosph-neuro
    granin
    		• fig3_CaMKII
    Accession No. : 2
  • Shared_Object_
    fig3_CaMKII
    Pathway No. : 12
    		• 28.62750.584.03448explicit E-S complexSubstrate
    neurogranin

    Product
    neurogranin*
    2PKC-active /
  • PKC-phosph-ng-Ca
    M
    		• fig3_CaMKII
    Accession No. : 2
  • Shared_Object_
    fig3_CaMKII
    Pathway No. : 12
    		• 28.59480.354explicit E-S complexSubstrate
    neurogranin-CaM

    Product
    CaM
    neurogranin*
    3PKC-active /
    phosph-AC2
    		fig3_CaMKII
    Accession No. : 2
  • Shared_Object_
    fig3_CaMKII
    Pathway No. : 12
    		• 33.333344explicit E-S complexSubstrate
    AC2

    Product
    AC2*


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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