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Molecule Parameter List for CaMKII***

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CaMKII*** participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	2	2	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig3_CaMKII	2	Network	Shared_Object_fig3_CaMKII,  CaMKII,  CaM,   PP1,  PP2B,  PKA,   AC
This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse. Demonstration script files for generating the figures in the paper, including figure 3, are available here.

CaMKII*** acting as a Molecule in  fig3_CaMKII Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII***	fig3_CaMKII Accession No. : 2	CaMKII Pathway No. : 13	0	1000	No

CaMKII*** acting as a Summed Molecule in  fig3_CaMKII Network

Accession Name	Pathway Name	Target	Input
fig3_CaMKII Accession No. : 2	CaMKII Pathway No. : 13	tot_autonomous_CaMKII	CaMKII-thr286 CaMKII***

CaMKII*** acting as a Substrate for an Enzyme in  fig3_CaMKII Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP1-active  / Deph-thr305	fig3_CaMKII Accession No. : 2	Shared_Object_ fig3_CaMKII Pathway No. : 12	5.09907	0.35	4	explicit E-S complex	Substrate CaMKII*** Product CaMKII-thr286
2	PP1-active  / Deph-thr286c	fig3_CaMKII Accession No. : 2	Shared_Object_ fig3_CaMKII Pathway No. : 12	5.09907	0.35	4	explicit E-S complex	Substrate CaMKII*** Product CaMK-thr306

CaMKII*** acting as a Product of an Enzyme in  fig3_CaMKII Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot_CaM_CaMKII  / CaM_act_305	fig3_CaMKII Accession No. : 2	CaMKII Pathway No. : 13	0.00000270563	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***
2	tot_autonomous_ CaMKII  / auton_305	fig3_CaMKII Accession No. : 2	CaMKII Pathway No. : 13	0.00000416667	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***